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Heterocyclic Amine - an overview | ScienceDirect Topics
- https://www.sciencedirect.com/topics/pharmacology-toxicology-and-pharmaceutical-science/heterocyclic-amine
- Erika L. Abel, John DiGiovanni, in The Molecular Basis of Cancer (Fourth Edition), 2015 Heterocyclic Amine Biotransformation. Heterocyclic amines, found in cooked meat and fish, are initially activated to genotoxic metabolites via CYP450-mediated oxidation to the N-hydroxyl derivative (see Figure 7-6). 42 In particular, this reaction is catalyzed in the liver predominantly …
Heterocyclic Amine - an overview | ScienceDirect Topics
- https://www.sciencedirect.com/topics/nursing-and-health-professions/heterocyclic-amine
- S.-W. Choi, J.B. Mason, in Encyclopedia of Food Sciences and Nutrition (Second Edition), 2003 Heterocyclic Amines. Heterocyclic amines (HCAs) are the carcinogenic and mutagenic chemicals formed from cooking muscle meats such as beef, pork, fowl, and fish. HCAs form when amino acids and creatine react at high cooking temperatures and are formed in greater quantities …
Heterocyclic Amines - University of Illinois Urbana-Champaign
- http://www.chem.uiuc.edu/organic/Amines/Chapter%2010/sec10-9/10-9.htm
- Heterocyclic Amines. If the nitrogen atom of an amine is incorporated as part of a ring, the resulting amine is said to be a heterocyclic compound one of a group of compounds whose rings contain at least one element other than carbon. Heterocyclic compounds containing oxygen, sulfur, or other elements are also known; however, heterocyclic nitrogen compounds are the …
Heterocyclic amines: chemistry and health - PubMed
- https://pubmed.ncbi.nlm.nih.gov/17131456/
- Heterocyclic amines (HAs) occur at the ppb range in foods. Most of them demonstrate potent mutagenicity in bacteria mutagenicity test, and some of them have been classified by the International Agency for Research on Cancer as probable/possible human carcinogens. Their capability of formation even during ordinary cooking practices implies ...
Heterocyclic amine formation and the impact of structure …
- https://www.sciencedirect.com/science/article/pii/S030438359900141X
- Nine heterocyclic amines were found in the meats and the corresponding meat drippings. The concentrations (calculated on a ng/g uncooked weight basis) are shown in Fig. 1. MeIQx, DiMeIQx, PhIP, DMIP and IFP were detected in all the samples. IQ and MeIQ were only detected in the fish meat drippings, and IQx in the beef meat drippings.
Chromatographic methods for the analysis of …
- https://pubmed.ncbi.nlm.nih.gov/1494008/
- A series of potent heterocyclic amines that are mutagenic and carcinogenic have been discovered that are formed in some heated foods, most notably, meats derived from muscle. Determining the heterocyclic amine content in foods and food products is required for toxicological research, industry qualit …
Metabolism and biomarkers of heterocyclic aromatic …
- https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8284014/
- Heterocyclic aromatic amines (HAAs) form during the high-temperature cooking of meats, poultry, and fish. Some HAAs also arise during the combustion of tobacco. HAAs are multisite carcinogens in rodents, inducing cancer of the liver, gastrointestinal tract, pancreas, mammary, and prostate glands. HAAs undergo metabolic activation by N ...
An epidemiologic approach to studying heterocyclic amines
- https://pubmed.ncbi.nlm.nih.gov/12351159/
- The association with red meat intake may be due to a combination of factors, such as content of fat, protein, and iron, and/or meat preparation (e.g. cooking or preserving methods). Laboratory results have shown that meats cooked at high temperatures contain heterocyclic amines (HCAs) known to be mutagenic and carcinogenic in animals.
Analysis of heterocyclic aromatic amines using selective …
- https://www.jfda-online.com/cgi/viewcontent.cgi?article=3384&context=journal
- Heterocyclic aromatic amines (HCAs) are highly carcinogenic and mutagenic chemicals. This study reports on the development of magnetic molecularly imprinted polymers (MMIPs) for the purification and quantification of HCAs. A novel magnetic molecularly imprinted polymer was successfully prepared using a surface molecular imprinting method
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